2013 Experimental Biology

The New Hygiene Hypothesis: Nutrition and Microbiota in Health and Disease

April 21, 2013

A major area of basic and translational research interest in nutrition involves the impact of “the Western lifestyle” on an increased immune-mediated disease burden, e.g., allergy and autoimmune disease, over the last several decades.  The basis for this altered disease burden in developed countries has been attributed to an inadequate initial bacterial colonization (original “hygiene hypothesis”) and a dysfunctional immune system. More recently several important studies have implicated diet in this process (new “hygiene hypothesis”). A Western style diet affects the microbiota of the gut which impacts on the development of an inadequate mucosal immune system with a decrease in sIgA and T-regulatory cytokines and increase in inflammatory cytokines. Several seminal recent publications have identified the importance of diet in this paradigm and new research is forthcoming. Accordingly, we propose a seminar to cover the nutritional impact on microbiota in health and disease.

No webcast recordings are available for this event.

Session Chairs

Allan Walker, MD
Conrad Taff Professor of Nutrition
Director, Division of Nutrition Harvard Medical School
Director, Mucosal Immunology Laboratory
Massachusetts General Hospital, Boston, MA

Simin Meydani, DVM, PhD
Director, Jean Mayer USDA Human Nutrition
Research Center on Aging at Tufts University
Professor of Nutrition and Immunology
Friedman School of Nutrition Science and Policy,
and Sackler Graduate School at Tufts University


Impact of Diet on Gut Microbiota in Afica and Europe

Dr. Paolo Lionetti
Associate Professor, Department of Pediatrics
University of Florence

Gut Microbiota Response to Diet in Gnotobiotic Mice

Jeremiah Faith, PhD
Assistant Professor, Icahn School of Medicine
at Mt. Sinai Immunology Institute,
Institute for Genomics and Multiscale Biology

Long-term Dietary Patterns in Gut Microbiota Enterotypes

Gary Wu, MD
Professor of Medicine, Division of Gastroenterology
Perelman School of Medicine,
University of Pennsylvania

Role of Breast Feeding in the Initial Gut Microbial Response

David Mills, PhD
Peter J. Shields Endowed Chair in Dairy Food Science
Department of Food Science and Technology
Department of Viticulture and Enology
University of California

Sponsored by Danone Research and Yakult Honsha, Co., Ltd., Harvard Medical School Division of Nutrition and Nutrition Obesity Research Center at Harvard, Boston Nutrition Obesity Research Center and Harvard School of Public Health Department of Nutrition